2011-07-21

BAH domain

BAH domain

BAH
PDB 1m4z EBI.jpg
crystal structure of the n-terminal bah domain of orc1p
Identifiers
Symbol BAH
Pfam PF01426
InterPro IPR001025
MEROPS C89
SCOP 1m4z

In molecular biology, the BAH domain (bromo-adjacent homology) domain is found in proteins such as eukaryotic DNA (cytosine-5) methyltransferases, the origin recognition complex 1 (Orc1) proteins, as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialised in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH domain might therefore play an important role by linking DNA methylation, replication and transcriptional regulation.

References

This article includes text from the public domain Pfam and InterPro IPR001025






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