2011-05-12

Furall

Furazolidone

Furazolidone
Systematic (IUPAC) name
3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Identifiers
CAS number 67-45-8
ATC code G01AX06
PubChem CID 3435
DrugBank DB00614
ChemSpider 3317
UNII 5J9CPU3RE0
ChEMBL CHEMBL1103
Chemical data
Formula C8H7N3O5
Mol. mass 225.16
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat. ?
Legal status ?
Routes Oral-Local
Yes(what is this?) (verify)

Furazolidone is an antibacterial. It is marketed by under the brand name Furoxone and by GlaxoSmithKline as Dependal-M.

Uses

It is used to treat diarrhoea and enteritis caused by bacteria or protozoan infections.

It has been used in aquaculture.

Protozoan

Furazolidone is also used for Giardiasis (due to Giardia lamblia), though it is not a first line treatment.

Bacterial

Furazolidone is also used to treat traveler's diarrhoea, cholera, and bacteremic salmonellosis.

As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections.

Use in treating Helicobacter pylori infections has been proposed.

Mechanism

It is believed to work by crosslinking of DNA.

Side effects

Furazolidone is no longer available in the US. Though an effective antibiotic when all others fail, against extremely drug resistant infections, it has many side effects, and as with other nitrofurans generally, minimum inhibitory concentrations also produce systemic toxicity (tremors, convulsions, peripheral neuritis, gastrointestinal disturbances, depression of spermatogenesis.) Nitrofurans are recognized by FDA as mutagens/carcinogens, and can no longer be used since 1991.

References






Retrieved from : http://en.wikipedia.org/wiki/Furazolidone