Hydrochlorothiazide/losartan
Hydrochlorothiazide/losartan is a combination drug used as an antihypertensive, consisting of hydrochlorothiazide (a diuretic) and losartan (an angiotensin II receptor antagonist).
The losartan/hydrochlorothiazide combination preparation is marketed by Merck under the trade name Hyzaar and by Xeno Pharmaceuticals under the name Anzaplus. In the Philippines, it is manufactured by the local company Chira Pharmaceuticals and sold as 2Zaris. Merck, Sharp & Dohme market it as Ocsaar Plus in Israel. It is marketed as Cozaar comp in Sweden.
In 2010, the patent for the combination expired, and Teva promptly filed and received approval to sell the generic losartan, with and without hydrochlorothiazide, in the United States.
Dosage
The recommended dosage of losartan-hydrochlorothiazide for people with high blood pressure (hypertension) will vary between losartan-hydrochlorothiazide 50 mg/12.5 mg and losartan-hydrochlorothiazide 100 mg/25 mg once a day. Based on the initial blood pressure response and/or losartan-hydrochlorothiazide side effects, the dosage may be increased or decreased. With each change in dosage, it may take up to a month to see the full effects of losartan-hydrochlorothiazide on lowering blood pressure.
References
Retrieved from : http://en.wikipedia.org/wiki/Hydrochlorothiazide/losartan
